{"id":357,"date":"2015-01-23T13:41:10","date_gmt":"2015-01-23T15:41:10","guid":{"rendered":"http:\/\/www.planetaw.com.br\/temp\/sbg\/?p=357"},"modified":"2019-06-11T13:08:42","modified_gmt":"2019-06-11T16:08:42","slug":"avaliacao-macular-pelo-oct-em-olhos-com-defeitos-campimetricos-paracentrais","status":"publish","type":"post","link":"https:\/\/www.sbglaucoma.org.br\/medico\/avaliacao-macular-pelo-oct-em-olhos-com-defeitos-campimetricos-paracentrais\/","title":{"rendered":"AVALIA\u00c7\u00c3O MACULAR PELO OCT EM OLHOS COM DEFEITOS CAMPIM\u00c9TRICOS PARACENTRAIS"},"content":{"rendered":"<div class=\"row-fluid\">\n<div class=\"span6\"><span class=\"tituloDoutorEsq\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-823 size-thumbnail\" src=\"https:\/\/sbglaucoma.org.br\/medico\/wp-content\/uploads\/2015\/01\/diego_torres-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" \/><strong>Artigo comentado por<\/strong>:<br \/>\nDr. Diego Torres, m\u00e9dico-oftalmologista,<br \/>\nfellow do 1\u00ba ano do Servi\u00e7o de Glaucoma,<br \/>\nDepartamento de Oftalmologia e Ci\u00eancias Visuais, EPM-HSP-UNIFESP.<br \/>\n<\/span><\/div>\n<div class=\"span6\"><span class=\"tituloDoutorEsq\"><img loading=\"lazy\" decoding=\"async\" class=\"borderLeft alignleft wp-image-824 size-full\" src=\"https:\/\/sbglaucoma.org.br\/medico\/wp-content\/uploads\/2015\/01\/ivan_tavares.jpg\" alt=\"\" width=\"100\" height=\"120\" \/><strong>Editor Associado<\/strong><br \/>\n<strong>Prof.Dr. Ivan Maynart Tavares<\/strong><br \/>\n<\/span><\/div>\n<\/div>\n<p>Estabelecer o limite que separa um paciente com suspeita de glaucoma de um paciente com glaucoma inicial \u00e9 uma tarefa desafiadora que envolve a an\u00e1lise conjunta de fatores de risco e par\u00e2metros estruturais e funcionais do paciente. A Tomografia de Coer\u00eancia \u00d3ptica (OCT) tem um papel importante nesta situa\u00e7\u00e3o e o aperfei\u00e7oamento desta tecnologia faz com que seja poss\u00edvel uma avalia\u00e7\u00e3o estrutural cada vez mais precisa.<span class=\"destaqueBgVerdeFloat\">Esses dados sugerem que em pacientes que iniciam defeitos de campo visual com escotomas parafoveais existe uma perda de c\u00e9lulas ganglionares mais acentuada na regi\u00e3o paracentral, por isso melhor avaliada com o OCT macular<\/span>, enquanto naqueles que iniciam o defeito de campo visual com degrau nasal essa perda \u00e9 mais afastada da f\u00f3vea, por isso menos detect\u00e1vel pelo OCT macular.<br \/>\n<strong>Um par\u00e2metro estrutural que tenha essa capacidade de discriminar olhos normais de olhos com glaucoma inicial \u00e9 algo que tem sido cada vez mais buscado com a evolu\u00e7\u00e3o das tecnologias de imagem ocular, por\u00e9m ainda n\u00e3o alcan\u00e7ado<\/strong>. Atualmente, a medida da espessura da camada de fibras nervosas (CFN) peripapilar pelo OCT destaca-se nesta an\u00e1lise por sua alta sensibilidade e especificidade, apesar de n\u00e3o poder ser utilizado como par\u00e2metro \u00fanico. Outro par\u00e2metro proposto mais recentemente com este intuito \u00e9 a medida da espessura das camadas plexiforme interna e de c\u00e9lulas ganglionares da regi\u00e3o macular, obtida por meio do algoritmo de an\u00e1lise de c\u00e9lulas ganglionares (GCA) do HD-OCT (Carl Zeiss Meditec, Dublin, CA).<br \/>\nDiante da hip\u00f3tese de que defeitos iniciais do campo visual em localiza\u00e7\u00f5es diferentes possam corresponder a perda de c\u00e9lulas ganglionares em regi\u00f5es diferentes, o estudo buscou comparar a capacidade da espessura da CFN peripapilar e da camada plexiforme interna e de c\u00e9lulas ganglionares macular de distinguir olhos normais de olhos com glaucoma inicial, dependendo da localiza\u00e7\u00e3o do defeito inicial do campo visual.<strong> Para isso foram estudados, de modo retrospectivo, 43 controles e 84 pacientes com glaucoma (42 com degrau nasal e 42 com escotoma paracentral na perimetria).<\/strong> As curvas ROC avaliaram a habilidade dos par\u00e2metros de detectar mudan\u00e7as glaucomatosas e as \u00e1reas sob a curva ROC foram calculadas para estimar a habilidade diagn\u00f3stica de cada par\u00e2metro.<br \/>\nO estudo demonstrou que, para o diagn\u00f3stico de glaucoma precoce, as espessuras (m\u00e9dia, m\u00ednima, inferior e inferotemporal) da camada plexiforme interna e de c\u00e9lulas ganglionares macular foram mais \u00fateis no grupo de pacientes com escotoma paracentral do que a espessura da CFN peripapilar (p = 0,042,0,025,0,001 e 0,007, respectivamente) e o inverso aconteceu em pacientes com degrau nasal. Esses dados sugerem que em pacientes que iniciam defeitos de campo visual com escotomas parafoveais existe uma perda de c\u00e9lulas ganglionares mais acentuada na regi\u00e3o paracentral, por isso melhor avaliada com o OCT macular, enquanto naqueles que iniciam o defeito de campo visual com degrau nasal essa perda \u00e9 mais afastada da f\u00f3vea, por isso menos detect\u00e1vel pelo OCT macular. <strong>Esses achados refor\u00e7am a import\u00e2ncia de sempre buscar estabelecer um racioc\u00ednio cl\u00ednico correlacionando estrutura e fun\u00e7\u00e3o ao se avaliar uma perda visual por glaucoma.<\/strong><br \/>\n<strong> Finalmente, h\u00e1 cada vez mais evid\u00eancias sugerindo que principalmente os pacientes com defeitos paracentrais dentro dos 10o centrais do campo visual se beneficiam da avalia\u00e7\u00e3o individualizada com estrat\u00e9gias espec\u00edficas de perimetria e OCT para essa regi\u00e3o. Todavia \u00e9 fundamental conhecer as limita\u00e7\u00f5es dos exames estruturais e funcionais e utiliz\u00e1-los como complementares ao exame cl\u00ednico e n\u00e3o como definidores de doen\u00e7a.<\/strong><\/p>\n<div class=\"envolveConteudo\">\n<div class=\"accordion-noticias\">\n<h3 style=\"background-color: #DADADA;\"><img decoding=\"async\" src=\"https:\/\/sbglaucoma.org.br\/medico\/wp-content\/uploads\/2015\/03\/seg.png\" \/>Resumo deste artigo<\/h3>\n<div>\n<div class=\"accordion-resumo\">\n<div class=\"box-isolado\">\n<p>\n<em>Ophthalmology<\/em>. 2014 Jan;121(1):93-9. doi: 10.1016\/j.ophtha.2013.06.041. Epub 2013 Aug 17.<br \/>\n<strong>Glaucoma diagnostic ability of ganglion cell-inner plexiform layer thickness differs according to the location of visual field loss<\/strong>.<br \/>\nShin HY1, Park HY1, Jung KI1, Choi JA1, Park CK2.<br \/>\n<strong>Author information<\/strong><\/p>\n<p><strong>Abstract<\/strong><br \/>\n<strong>OBJECTIVE<\/strong>:<br \/>\nTo determine whether the ganglion cell-inner plexiform layer (GCIPL) or circumpapillary retinal nerve fiber layer (cpRNFL) is better at distinguishing eyes with early glaucoma from normal eyes on the basis of the the initial location of the visual field (VF) damage.<\/p>\n<p><strong>DESIGN<\/strong>:<br \/>\nRetrospective, observational study.<\/p>\n<p><strong>PARTICIPANTS<\/strong>:<br \/>\nEighty-four patients with early glaucoma and 43 normal subjects were enrolled. The patients with glaucoma were subdivided into 2 groups according to the location of VF damage: (1) an isolated parafoveal scotoma (PFS, N = 42) within 12 points of a central 10 degrees in 1 hemifield or (2) an isolated peripheral nasal step (PNS, N = 42) within the nasal periphery outside 10 degrees of fixation in 1 hemifield.<\/p>\n<p><strong>METHODS<\/strong>:<br \/>\nAll patients underwent macular and optic disc scanning using Cirrus high-definition optical coherence tomography (Carl Zeiss Meditec, Dublin, CA). The GCIPL and cpRNFL thicknesses were compared between groups. Areas under the receiver operating characteristic curves (AUCs) were calculated.<\/p>\n<p><strong>MAIN OUTCOME MEASURES<\/strong>:<br \/>\nComparison of diagnostic ability using AUCs.<\/p>\n<p><strong>RESULTS<\/strong>:<br \/>\nThe average and minimum GCIPL of the PFS group were significantly thinner than those of the PNS group, whereas there was no significant difference in the average retinal nerve fiber layer (RNFL) thickness between the 2 groups. The AUCs of the average (0.962) and minimum GCIPL (0.973) thicknesses did not differ from that of the average RNFL thickness (0.972) for discriminating glaucomatous changes between normal and all glaucoma eyes (P\u2009=0.566 and 0.974, respectively). In the PFS group, the AUCs of the average (0.988) and minimum GCIPL (0.999) thicknesses were greater than that of the average RNFL thickness (0.961, P\u2009=0.307 and 0.125, respectively). However, the AUCs of the average (0.936) and minimum GCIPL (0.947) thicknesses were lower than that of the average RNFL thickness (0.984) in the PNS group (P\u2009=0.032 and 0.069, respectively).<\/p>\n<p><strong>CONCLUSIONS<\/strong>:<br \/>\nThe GCIPL parameters were more valuable than the cpRNFL parameters for detecting glaucoma in eyes with parafoveal VF loss, and the cpRNFL parameters were better than the GCIPL parameters for detecting glaucoma in eyes with peripheral VF loss. Clinicians should know that the diagnostic capability of macular GCIPL parameters depends largely on the location of the VF loss.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Artigo comentado por: Dr. Diego Torres, m\u00e9dico-oftalmologista, fellow do 1\u00ba ano do Servi\u00e7o de Glaucoma, Departamento de Oftalmologia e Ci\u00eancias Visuais, EPM-HSP-UNIFESP. Editor Associado Prof.Dr. Ivan Maynart Tavares Estabelecer o limite que separa um paciente com suspeita de glaucoma de um paciente com glaucoma inicial \u00e9 uma tarefa desafiadora que envolve a an\u00e1lise conjunta de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_joinchat":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-357","post","type-post","status-publish","format-standard","hentry","category-sem-categoria"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AVALIA\u00c7\u00c3O MACULAR PELO OCT EM OLHOS COM DEFEITOS CAMPIM\u00c9TRICOS PARACENTRAIS - SBG - Sociedade Brasileira de Glaucoma<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sbglaucoma.org.br\/medico\/avaliacao-macular-pelo-oct-em-olhos-com-defeitos-campimetricos-paracentrais\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AVALIA\u00c7\u00c3O MACULAR PELO OCT EM OLHOS COM DEFEITOS CAMPIM\u00c9TRICOS PARACENTRAIS - SBG - Sociedade Brasileira de Glaucoma\" \/>\n<meta property=\"og:description\" content=\"Artigo comentado por: Dr. Diego Torres, m\u00e9dico-oftalmologista, fellow do 1\u00ba ano do Servi\u00e7o de Glaucoma, Departamento de Oftalmologia e Ci\u00eancias Visuais, EPM-HSP-UNIFESP. 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